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ea0099oc11.4 | Oral Communications 11: Adrenal and Cardiovascular Endocrinology | Part II | ECE2024

Machine learning-based differentiation of uni- and bilateral primary aldosteronism using circulating microRNA combinations

Vekony Balint , Nyirő Gabor , Herold Zoltan , Fekete Janos , Ceccato Filiipo , Gruber Sven , Kurzinger Lydia , Parasiliti-Caprino Mirko , Szucs Nikolette , Szeredas Balint , Nazri Siti Khadija Syed Mohammed , Fell Vanessa , Bassiony Mohamed , Azizan Elena A B Aisha , Bancos Irina , Beuschlein Felix , Igaz Peter

Background: Primary aldosteronism (PA) is the most prevalent cause of secondary hypertension. Its two main clinical forms are unilateral adenoma (APA) and bilateral hyperplasia (BAH), which require markedly different medical treatments, so differentiating between the two is of utmost clinical importance. The current gold standard method for this is adrenal vein sampling (AVS), the application of which is hindered by limited availability and high skill requirements.AimOur goal ...

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ea0099rc13.3 | Rapid Communications 13: Late Breaking | ECE2024

Comparison of metyrapone, osilodrostat and ketoconazole in the therapy of endogenous Cushing’s syndrome: The MOSKETEER study

Detomas Mario , Ceccato Filippo , Simeoli Chiara , Dolce Pasquale , Aulinas Maso Ana , Gilis-Januszewska Aleksandra , Parasiliti Caprino Mirko , Bassiony Mohamed , Stelmachowska-Banaś Maria , Ferrante Emanuele , Pittaway James , Rubinstein German , Hanzu Felicia A , Pmglisi Soraya , Corsello Andrea , Antonini Simone , Sambula Lana , Minnetti Marianna , Haberbosch Linus , Deutschbein Timo , Dischinger Ulrich , Voltan Giacomo , Di Paola Nicola , Santos Vives Alicia , Minasyan Mari , Giordano Roberta , Fell Vanessa , Cylke-Falkowska Karolina , Mangone Alessandra , Plowman Christina , Vega Arturo , Braun Leah , Mazzarella Alessandro , Locantore Pietro , Faggiano Antongiulio , Terzolo Massimo , Lania Andrea , Kastelan Darko , Isidori Andrea , Reincke Martin , Bancos Irina , Arvat Emanuela , Webb Susan M , Carla Scaroni , Pivonello Rosario , Fassnacht Martin , Altieri Barbara

Background: Metyrapone, osilodrostat, and ketoconazole are steroidogenesis inhibitors used as second-line treatment in endogenous Cushings syndrome (CS). However, a direct comparison of these three drmgs is missing.Objective: To compare the efficacy of the three drmgs after short-term therapy (≤12 weeks) for CS.Methods: Multicenter, real-life retrospective study involving 20 centers worldwide. Patients with CS treated w...

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Endocrine Abstracts

Machine learning-based differentiation of uni- and bilateral primary aldosteronism using circulating microRNA combinations

Comparison of metyrapone, osilodrostat and ketoconazole in the therapy of endogenous Cushing’s syndrome: The MOSKETEER study

BiosciAbstracts